The innovation of higher education system is one of the concrete practices of comprehensively implementing the Party's educational policy. Xuanwu Hospital, as the first clinical School of Medicine of Capital Medical University, has the advantage of integrating theory and practice. Focusing on the "Three-all" holistic education as the core and focusing on the important task of serving high-quality development of medical education, it has explored and practiced the "four-strengthen and four-promote" education system, namely, "strengthen thought guidance, promoting integration of socialist mind and profession", "strengthen reform and innovation, promote endogenous drive", "strengthen interdisciplinary research, promote coordinated development", "strengthen platform construction, promote horizon expansion". Therefore, this study has effectively stimulated the fundamental driving force of education reform and innovation, and has achieved good results.