The study constructs a blended model of genre-based English academic writing course for medical students, which involves constructing genre models online, deconstructing genre structures in class and co-constructing discourse online. Writing instruction is driven by an academic writing program and guided by students' online reading and writing performances, engaging students in activities of mind map drawing, literature analysis presentation and research article writing. Qualitative and quantitative data show this model improves medical students' academic English reading and writing abilities, and enhances their autonomous learning and deep learning abilities.