Abstract: Objective　To compare the application effect of project-driven teaching method under the constructivism learning theory in the basic nursing classroom teaching of undergraduate nursing majors, and to explore the impact on students' autonomous learning ability and humanistic caring ability.Methods　A total of 193 students from 4 classes of 2022 majoring in nursing from School of Nursing, Xinjiang Medical University were selected as the research objects, 97 in the experimental group and 96 in the control group. The experimental group adopted project-driven teaching under the constructivism concept. The control group was taught with the investigatory 5W case teaching method (What, Why, Where, Way, When).Results　There was no significant difference between the two groups (t=1.35, P=0.09). The practical performance of test group was higher than that of control group, and the difference was statistically significant (t=8.31, P＜0.01). The result of process evaluation of test group was higher than that of control group, and the difference was statistically significant (t=6.95, P＜0.01). The autonomous learning ability of test group was higher than that of control group, and the difference was statistically significant (t=3.72, P＜0.01). The humanistic caring ability of experimental group was higher than that of control group, and the difference was statistically significant (t=-2.38, P＜0.01).Conclusion　The project-driven teaching under the constructivism learning theory in basic nursing curriculum is conducive to improving students' academic performance, autonomous learning ability and humanistic care ability.

Key words: constructivist, project-driven teaching, basic nursing, nursing education