Abstract: Objective  To explore the application of problem-based learning (PBL) combined with 3D-slicer image reconstruction technology in neurosurgical clinical practice teaching for long-term-system medical students.  Methods  A total of 62 long-term-system medical students underwent neurosurgical clinical practice teaching in our department from April 2019 to June 2019 were selected. They were randomly divided into experimental group and control group. The control group received traditional teaching mode,  while the experimental group was given PBL teaching method combined with 3D-slicer image reconstruction mode. The teaching effect was evaluated by   clinical practice test,  theory examination， mini-clinical evaluation exercise (Mini-CEX) and student questionnaire. Results   The clinical practice test results,  theoretical assessment results and Mini-CEX results (all P<0.05) in experimental group were significantly higher than those in control group. According to the questionnaire survey,  students in experimental group were more satisfied with the class atmosphere,  radiological image evaluation,  operation explanation and satisfaction of teaching than those in control group ( all P<0.05). Conclusion  In the neurosurgical clinical practice teaching in long-term-system medical students,  PBL teaching method combined with 3D-SLicer image reconstruction technology can stimulate students' interest and initiative in neurosurgical practice learning,  improve the learning efficiency and the teaching effect.

Key words: 3D-slicer software, problem-based learning, mini-clinical evaluation exercise, long-term-system clinical medicine, neurosurgery, clinical practice teaching