Abstract: Objective To explore the application of innovative thinking-oriented teaching method in undergraduate students’ experimental skills of Basic Nursing Science. Methods Two natural classes of undergraduates were divided into an experimental group and a control group, each 37 students. The experimental group were used reformed teaching methods, including watching videos, designing scripts and conducting exhibition competitions, and open discussion. It mainly highlights the time and platform for students to take more self-learning and self-practice exploration. The control group were used the traditional teaching methods. The self-evaluation results of the students’ comprehensive quality, after-class test scores and nursing skills operation scores of the two groups were compared. Results The experimental group students’ self-assessment improvement of the comprehensive quality of study interest, innovation consciousness and innovative thinking was higher than that of the control group students (P<0.05). The test scores and operational assessment scores of the experimental group students were higher than those of the control group (P<0.001, P<0.05). Conclusion The innovative thinking-oriented teaching method is conducive to improving the comprehensive quality of undergraduate students' innovative consciousness, innovative thinking, learning interest, independent learning and cooperative learning ability.

Key words: Basic Nursing Science, experimental teaching, innovative thinking, teaching method