Abstract: Objective  To evaluate the effect of blended teaching based on the training of integrative thinking in biochemistry and molecular biology teaching. Methods  A total of 28 students from five-year clinical medicine in Grade 2015 and 63 students of clinical medicine (including pediatrics, psychiatry) and pharmacy in Grade 2018 were recruited as two independent cohorts. Teaching in traditional classroom blended with online teaching which includes email and WeChat communication was introduced into the course of biochemistry and molecular biology for the training of medical integrative thinking. Results   Compared with the students who studied with traditional teaching methods, the average score of the final examination for those students who took part in the training was higher than that of the whole class. The results of the questionnaire survey showed that the students highly appreciated the blended teaching method, and their learning interest, autonomous learning ability, integrative thinking ability of clinical medicine, and team cooperation ability were improved. Conclusion  The application of blended teaching based on integrated thinking in biochemistry and molecular biology is feasible, and desirable teaching effect has been achieved. However, it still needs many conditions and investment to promote the implementation of blended teaching in medical colleges and universities.

Key words: integrative thinking, biochemistry, molecular biology, blended teaching, medical education reform