Abstract: The model of overall health humanities education is based on the “Five-Full” concept, which means fullman, full-aspect, full-course, full-time, and full-dimensional, as well as the combination of general and professional education. In theory and in practice, it focuses on the humanities and health education and the health literacy improvement of medical students. This study used the random cluster sampling to select 1021 college students from a medical university as objectives. A three-year empirical study of the overall health humanities education was conducted through the staged questionnaire survey, and then analyzed the change of health literacy among college students to make a scientific evaluation of the model implement effect.