Abstract: Objective　To promote high quality design and implementation of Investigator-Initiated Trail (IIT) in stomatology.Methods　Combining with the actual work, the problems and causes of IIT in stomatology were systematically sorted out, and the corresponding countermeasures were put forward from the perspective of management through literature review.Results　There exist some problems in IIT in stomatology, such as lack of standardization in research design, insufficient ethical review and subject protection awareness, failure to conduct research registration and filing in accordance with regulations, lack of quality control.Conclusion　Medical institutions should play the main responsibility of IIT management, collaborate with various management platforms and combine the characteristics of stomatology, establish smooth management paths, strengthen the two-way training of scientific researchers and management personnel to promoting the development of stomatology.

Key words: investigator-initiated trial, problems, management optimization