Abstract: n the deepening of teaching reform, to better learn and master theoretical knowledge, how to draw a reasonable conclusion through experimental teaching, it is a question that we have been thinking and exploring in the experimental teaching. In recent years, our emphasis in the reform of experimental teaching is to maintain the integrity of the whole experimental process, strengthen the cultivation of students’ scientific research thinking ability and practical ability. Therefore, the teaching and research department has carried out a preliminary reform and exploration of the experimental content and mode, open experiment and comprehensive design experiment were carried out, and the PBL teaching mode is explored, combining the Application of Network Platform, in order to improve the teaching effect of medical immunology experiment, improve students’ clinical practice ability and scientific research innovation ability.