Abstract: objective To investigate the status of academic self-efficacy in medicine-related higher vocational students,nd to explore the influencing factors and improving measures of academic self-efficacy. Method A questionnaire survey n self-efficacy compiled by Liang Yusong was conducted among 780 students in Suzhou Vocational Health College by he method of stratified cluster random sampling. Result The average scores of learning ability efficiency and learning ehavior efficiency of medicine-related higher vocational students were 38.68±5.426 and 36.58±4.891, respectively. There s a significant gender difference in the academic self-efficacy with male students higher than female students. The passing ate in the dimension of learning behavior effectiveness of freshmen is significantly higher than that of sophomores, and the ifference is statistically significant (P<0.05). There was no statistically significant difference in the academic self-efficacy of students enrolled from different sources and locations. Conclusion Some medicine-related higher vocational students have a low sense of academic self-efficacy, which should cause close attention. It is suggested to stimulate students’ interest in learning and cultivate professional identity to improve students' sense of academic self-efficacy by adjusting teaching strategies, improving teaching methods and other measures.