Abstract: The development of modern medicine and society puts forward higher requirements for the training mode of basic medical talents. Certain common problems exist in the experimental teaching of basic medicine in domestic colleges and universities, which are mainly manifested in the separation of teachers from students, the separation of basic medicine from clinical medicine, the separation of theory from practice, as well as the separation of teaching from scientific research. In recent years, Zhongshan Medical College, Sun Yat-sen University has actively promoted the experimental teaching reform of basic medicine for cultivation of top-notch innovative talents, and explored an integrated experimental teaching mode of basic medicine combining “first class” (experimental teaching in classroom) and “second class” (research practice in principal investigator laboratory). Through various teaching modules in “first class”, including comprehensive experiments, seminars and biosafety virtual experimental teaching, students can understand the corresponding frontier technology and scientific research progress. Meanwhile，through the research practice of PI laboratory in the “second class”, students can get the “one-to-one” guidance from scientific research tutors and systematic standardized scientific research training during the whole process, as well as complete innovative experimental design and opening defense. After five years of practice, this integrated experimental teaching mode of “dual class”in basic medicine is helpful to improve students autonomous learning ability, innovative thinking and scientific research practice ability, and therefore provides useful exploration and reference for the cultivation of top-notch talents in basic medicine.

Key words: basic medicine,  top-notch talents, integrated experimental teaching,  “dual class” mode