Abstract: The traditional chemistry experiment teaching methods need to be reformed. The activities in the second classroom as the continuation of the first classroom, can be used to improve students’ initiative and enthusiasm. The subject of soap handmaking can combine with the hot issues in production and life practice, with the consideration of environmental protection and health benefits. The handmade soaps were made by adding natural plant oil. The influence of material liquid ratio, hot-process soapmaking, cold process method, soap making time and so on is compared. The surface tension of the solution of handmade soap was determined by maximum bubble method. Producing Fe3O4 nanoparticles is another subject.Fe3O4 nanoparticles were prepared by co-precipitation method. The effects of molar ratio and pH are investigated. When the final products are finished, the students’ interest is stimulated. The second classroom can cultivate the students’ scientific thinking and innovation ability.