Abstract: During the process of intellectualization, the world plunges into 3.0 Times of Education featuring the diversified teaching resources and the individualized learning experience, which brings profound impact on the development of undergraduate teaching in medical universities and colleges. This paper sorts out four major challenges confronting undergraduate medical teaching in the context of 3.0 Times of Education. The challenges derive from four changes, namely,changes of social division of labor, teaching resources, knowledge structure and management concepts. On recognition of these challenges, this paper proposes some suggestions for the reform and development of medical undergraduate education under this new situation after presenting the reform exploration of Southern Medical University in the following four aspects, namely, the adjustment of teaching strategies, the optimization of teaching methods, the improvement of learning experiences and the upgrading of teaching management.