Abstract: With the current rise of the knowledge economy and fierce competition for talents, there are higher requirements for overall quality of medical students. Consequently, it is very important to cultivate undergraduates’ ability in scientifi c research and innovation. During the practices of mentoring the scientifi c research and innovation activities of medical undergraduates, the author gradually explored his own set of instruction and management system. In this paper, his own experience of mentoring the medical undergraduate was described and his own views on it was put forward. In short, through these activities, the undergraduates found research directions from the issues, accessed to the knowledge in practice, reinforced their theoretical foundation and broadened their course perspectives. With the reform of higher medical education, more smart, qualified and innovative talents will be cultivated and delivered to the society through these scientifi c research and innovation activities.