Abstract: According to series of quality projects and undergraduate educational projects, characteristic nursing was established and its educational feature and professional structure adapt to needs of national healthcare development, with an aim to enhance teachers team construction, to improve students’ practice and innovation ability as well as to establish applied undergraduate nursing talent training mode with solid foundation, excellent ability, high quality and focus on development.Combined the needs of nursing talents in healthcare development and concept of “Whole-person education”, “1234” undergraduate nursing talent training mode was set up, emphasizing on “One principle, Two abilities, Three systems and Four outcomes”. “One principle” is that medical humanistic quality education runs throughout whole process of undergraduate nursing talents’ training. “Two abilities” focus on improvement of ability of integrated theory with practice and professional development. “Three systems” involve undergraduate nursing education system combined general education and specialist training, practice system and teaching quality assurance system based on construction of comprehensive teachers team.“Four outcomes” is reflected from the following aspects: coordinated development of knowledge, skills and qualities; solid foundation and broad horizon; independent study ability, integrated theory with practice ability and innovative spirit; and ability of obtaining and regenerating knowledge.