Abstract: Hegel's thought on natural philosophy is an important part of his grand philosophy world, which has a profound influence on the development of later philosophy and sciences. Hegel's natural philosophy is based on the thought of Kant 's thing-in-itself and it is also the process of sublation and transformation. In Hegel's view, thing-it-self is the pure existence in all things, it is not a material and nor spirit, nor subject to any special quality or any time and any space. Hegel's thought on natural philosophy also contains a wealth of dialectics thinking. Based on Hegel's understanding of thing-in-itself, this paper is mainly discussed the formation and influence of Hegel's thought natural philosophy.