Abstract: The think-tank construction in China’s medical colleges has already started and is developing steadily and orderly. To provide decision makers with reliable and practical suggestions, we should recognize the advantages of the talent, disciplines, research strength, academic communication in medical colleges; find out the insufficiency in mechanism function, standard of talent, the research model and think-tank role; take health development and clinical disease resolution as the core research of the medical think tank, and carry out strategic planning and comprehensive analysis.