Abstract: Objective  To explore the building of clinical training mode with the post competence as a core, in order to  cultivate qualified medical talents.  Methods  After looking up the domestic and foreign literature, questionnaire survey,  brainstorming, expert consultation and other research methods, the teaching experts from school and the experienced clinical  teachers had been invited to discuss the training content and curriculum plan, the organization management system and  organization framework, the positioning objective, the preparation of syllabus, the refi nement of curriculum implementation  plan and the improvement of evaluation system, which were applied in the 2008, 2009 and 2010 steps of long-term system  undergraduates’ clinical practice, to make multi-faceted questionnaire survey and evaluation.  Results  The evaluation effect  of the training scheme were well through the questionnaire of feedback from students, teachers, practice departments, the  formative assessment of practice, and the analysis and comparison of students’ results of examination. Conclusion  The  training mode of medical talents with the post competence as a core can help to improve medical students' comprehensive  ability in clinical practice.