Abstract: Focus on the weakness of clinical and research training of typical endocrine diseases for postgraduate, based on typical endocrine diseases model to accumulate and develop the structure of endocrine knowledge, craniopharyngioma (impairment of hypothalamus-pituitary-target gland) was applied as a typical endocrine dysfunction model to complete the training course of clinical and research competencies, and to develop and widen the structures of the endocrine knowledge. During this training course of clinical ability, around above aspects of theories accumulating and knowledge structure developing, the typical endocrine disease model either satisfi ed the main requirements for the clinical training of endocrine disease diagnosis and therapy, or achieved the objective of clinical training to draw inferences about other cases from one instance and comprehend by analogy. Through the training, the postgraduates would further abstract scientifi c proposals from the process of clinical training, to accomplish the clinical training as a translational medicine mode from bedside to bench, which would return to guide the clinical practice.