Abstract: Objective To train pathological diagnosis ability of central nervous system tumors of young pathologists and refresher pathologists will help improve the accuracy of the pathological diagnosis, which has important signifi cance for the patients' prognosis and chemoradiotherapy. Methods Young pathologists and refresher pathologists were trained by the process of reading pathology sections, mastering clinical information, applying diagnostic ideas and, if necessary, differential diagnosis, and ultimately making accurate pathological diagnosis. Results The pathological diagnosis ability of central nervous system tumors of young pathologists and refresher pathologists were improved and able to provide correct pathological diagnosis reports. Conclusion It is effective for improving the accuracy of pathological diagnosis by training pathologists to correctly read pathology sections and apply diagnostic ideas.