Abstract: Objective To explore the effectiveness of this teaching curriculum reform by implementing a new pediatric theory class and bedside teaching method for medical students in Wuhan University. Methods Five-year students of 2010,2011 and 2012 clinical medicine majors were selected as subjects and were divided into the control class (328) and the experimental class (68). The control class is taught by the traditional teaching method, and the experimental class adopts the WUMER teaching reform mode with CPPT as the core to compare and analyze the teaching effects of the two classes.Results With the advancement of teaching reform, the differences in theoretical scores and skill scores between control class and experimental class in each grade were narrowed, but the differences in theories, skills, and case analysis between two classes were statistically significant (P<0.05). Conclusion From three aspects of teaching content, teaching methods and assessment methods, result of the teaching reform of the pediatric curriculum has achieved, which can improve students’ clinical thinking and practical ability.