Abstract: Think-tanks in higher education is an indispensable component of the current think-tank in China. The construction of the think-tank in medical colleges has its necessity and its own characteristics. Combined with the characteristics of medical colleges, this paper adheres to problem-oriented principle, fully utilizes the advantages of research base, and actively carries out interdisciplinary research, and promotes the research results to the media for social science research initiative. Moreover, through the construction of social science think-tank in medical colleges, it vigorously promotes the transformation of social science achievements, and really enhances medical colleges for social influence and credibility.