Abstract: With the development of society and medical science, the goal of clinical teaching of infectious diseases has changed from pure cultivation of doctors to cultivating three-dimensional talents. In a teaching hospital, regulating the teaching responsibilities of various levels of physicians can ease the teaching pressure, and, the quality of teaching can be ensured through the collective lesson preparation method. According to different training objects, appropriate training programs and assessment indicators can be set up, and teaching plans can be arranged comprehensively within the whole hospital. According to the recent changes in infectious disease spectrum and diagnosis and treatment technologies, the content of teaching should be adjusted, and the humanistic spirit should be reflected in clinical teaching, and the cultivation of scientific research ability should also be taken into account. All kinds of teaching models have their own advantages and disadvantages, which should be applied comprehensively in the clinical teaching of infectious diseases.