Abstract: "Flipped class model" is a new teaching model with unique connotation and characteristics, student-centered and teacher-led. The introduction of such model is the requirement of development in infectious diseases teaching and the challenge of reform in education. A video courseware self-studying before class, problem-based learning (PBL) during class, and the construction of self and mutual evaluation system for students and teachers were applied to explore the application of “fl ipped class model” in the teaching of infectious diseases, which would provide new ideas for the reform and development in the teaching of infectious diseases.