Abstract: Objective To explore the effect of Seminar-case teaching method based on WeChat in clinical practice teaching of undergraduate nursing students. Methods To select 42 undergraduate nursing students as the control group in the grade of 2012 in hospital of Dalian by the convenience sampling method, 38 undergraduate nursing students as the experimental group in the grade of 2013. The control group adopted traditional clinical teaching method.The experimental group adopted the traditional teaching method and the Seminar- case method based on WeChat.The critical thinking ability and self-efficacy scale were used to evaluate two groups of nursing students before and after clinical practice. Results After the internship, the self-efficacy score of the experimental group was higher than that of the control group (P<0.05). Scores of critical thinking ability and searching for the truth, open mind, abilities of analysis, ability of systemati-zation, critical thinking, confidence, curiosity, cognitive maturity of the experimental group were higher than that of control group (P<0.05). Conclusion Seminar-case teaching method based on WeChat can improve its critical thinking ability and self-efficacy in the clinical practice of undergraduate nursing students,and then improve the clinical practice effect. It is worth popularizing and applying in clinical teaching.