Abstract: To observe the effect of the teaching model including lecture-based learning (LBL), case-based study (CBS),problem-based learning (PBL) and case-based learning (CBL), further talk about experience in our study. In medical college students teaching, all of the four teaching model including LBL, CBS, PBL, CBL were used, at the end of class the student teaching assessment forms, theoretical assessment scales and comprehensive skills assessment scales were tested to compare the effect of teaching. Compared to LBL, the teaching model of PBL and CBL obtained students’ acknowledgement and approval, the scores of theoretical assessment and comprehensive skills assessment were more higher than those of LBL.PBL and CBL are the teaching model that more suitable for medical undergraduate education. Comparison of the two teaching modes, PBL teaching is more suitable for small number students (students number about ten) and the students have lot of knowledge, ant CBL teaching is more suitable for class for the medical undergraduate education.