Abstract: Objective To explore the teaching effect of the intelligent classroom combined with task-driven teaching method in medical imaging teaching. Methods Four classes taking themedical imagingcourse were selected from Dalian Medical University from September 2018 to December 2018. They were divided into the study group (64 students accepting the intelligent classroom combined with task-driven teaching method) and the control group (64 students accepting traditional granting teaching method). At the end of the teaching, the teaching effect was evaluated through the classroom test, which included objective theoretical knowledge assessment and subjective assessment of the students.Statistical analysis was performed on the data using SPSS 19.0 software. Results The objective theoretical knowledge assessment scores of the study group (82.39±9.59) were higher than those of the control group (70±11.55), and the difference was significant (P<0.05). In terms of arousing learning interest, developing the thinking ability and skills of image diagnosis, cultivating the ability of independent thinking and solving problems, improving autonomic learning and innovative thinking in scientific research, the study group were higher than the control group respectively by (82.9% vs. 10.6%), (91.3% vs. 5.6%), (88.5% vs.7.8%), (86.7% vs. 9.2%), and the differences were significant (P<0.01). There was no statistical difference between the two groups of students’ recognition or expectation of teaching reform (93.3% vs. 85.4%). Conclusion The intelligent classroom combined with task-driven teaching method can significantly improve the quality of medical imaging teaching, better stimulate learning interest, and help to cultivate imaging diagnostic thinking mode and reading skills.