Abstract: Objective Through the investigation and analysis of learning situation of college students, to study some key issues of higher education reform from the perspectives of the students, in order to provide suggestion of higher education and teaching reform for reference. Methods An questionnaire investigation of learning situation was carried out on 3822 undergraduates of 2008 - 2011 and the obtained data were analyzed. Results The students' initiative to communicate with teachers and enthusiasm to learn should be paid attention, and the students' specialty was not a good match for their interests, the awareness of scientific research innovation was not strong enough. Conclusion It should be necessary to push college students actively communicate with their teachers, mobilize their enthusiasm for learning, advance their professional interest, and stimulate their critical thinking and innovation awareness.