Abstract: With the social development and progress, the construction of new engineering is essential for the new stage of national higher education development, and for the training talents in the industrial development of the new era. Under the background of vigorous development of new engineering, the talents training mode centers on innovative talents. Therefore,in recent years, colleges and universities pay more attention to students' innovation and entrepreneurship education. As an application-oriented university, it has gradually become a new topic of talent training mode in colleges and universities to innovate the traditional education mode, guide students to develop innovative ideas and establish entrepreneurship concept while cultivating application-oriented talents in traditional industries. This paper focuses on the exploration of multi-dimensional innovative talents training mode, and explores the effective innovative talents training mode in colleges and universities through the practice of establishing innovative entrepreneurship studios for students majoring in medical imaging under the premise of the permission of existing teaching resources.