Abstract: Local medical colleges and universities should closely focus on the regional economic and social development needs to perform the modern university function. Based on the relationship between the local medical colleges and universities and the regional economic and social developments, this article discussed the approaches by which the local medical colleges and universities contribute to their regional economic and social developments, from five perspectives: to make clear the university position; to reform the mechanisms of talent cultivation; to advance the development model of collaborative innovation; to strengthen university culture construction; and to promote the modernization of the governance systems and capacities.