Abstract: Objective To explore the application effectiveness of the “Smart Pharmacy” simulation-based practical training in pharmaceutical care skills teaching. Methods This study adopted a quasi-experimental research design. From September 2024 to September 2025, a total of 120 students from two parallel classes of the same grade and professional background (Grade 2022, pharmacy major) at Henan Medical University were selected as research subjects. Cluster grouping was performed by class: one class designated as the control group (n=60) and the other as the study group (n=60). The control group received traditional teaching methods, while the study group was additionally provided with "Smart Pharmacy" simulation‑based practical training on the basis of the control group. The scores of theoretical knowledge assessment and practical skills assessment were compared between the two groups, and teaching satisfaction was evaluated using a questionnaire survey. Results The total score of theoretical knowledge assessment in pharmaceutical care (85.13±7.02), the total score of practical skills assessment in pharmaceutical care (85.37±3.64), and the total score of teaching satisfaction (4.79±0.30) in the study group were all higher than those in the control group, with statistically significant differences (P<0.05). 
Conclusion As an innovative practical teaching model, the “Smart Pharmacy” simulation-based practical training can effectively improve the quality and efficiency of pharmaceutical care skills teaching, demonstrating significant advantages in cultivating students’ clinical thinking, communication skills, and professional competence. This study provides empirical evidence for the promotion of this platform in pharmacy education.

Key words: smart pharmacy, ｜ pharmaceutical care｜ skills teaching｜ teaching effectiveness｜ simulation training