Abstract: Led by the hospital characteristic culture and based on the practical problems of poor access and high fee, Da li Bai Autonomous Prefecture People's Hospital took the pilot reform of public hospitals as a project for people's livelihood and well-being, actively practiced and boldly explored, created some characteristic methods, and achieved the obvious effects of "culture-guided, two aspects of breakthrough, and three aspects of reduction", such as reducing the medical burden on patients, mobilizing the enthusiasm of medical staff, improving the hospital income structure, and easing the pressure in medical access and fee.