Abstract: The connotation construction in a university includes the construction of school-running concept and characteristics, specialties, ability in scientific and technological innovation, talent training quality, talent team, campus culture and etc. This article takes Inner Mongolia Medical University as an example to illustrate how to strengthen the connotation construction and promote the scientific development in the university. It includes the following aspects: to construct rational talent echelon and scientifically develop talent team; to deepen educational and teaching reform and improve the level of cultivating innovative talents; to build a scientifi c teaching and research platform for innovative science and technology talents to put their efforts into practice; to give full play to its own characteristics and advantages and promote high-level construction of medical university; to strengthen the construction of campus culture and create good educational environment. At the same time, this article also points out that currently China's higher education is moving into a new period of reform and development. Therefore, in order to build a large platform, form a large group, strive for a large project, achieve a large effect and build a major feature, a university should thoroughly implement the central government's strategic layout of "four overall aspects" and the Plan for education and development, accurately position, put the quality into the core, deepen the comprehensive reform, innovate mechanism and system, and vigorously promote collaborative innovation.