Abstract: Objective To understand the current situation and existing problems of the teaching mode of pediatric dermatology, and to explore the teaching concept and teaching effect of the innovative mode. Methods By comparing the new and old teaching modes, the problem-and case-based learning teaching method, the existing traditional teaching mode, the multimedia teaching and the network teaching method are organically combined, and they are applied in the basic and clinical teaching of the pediatric dermatology department. Results The innovation in the teaching mode of pediatric dermatology can effectively stimulate students’ learning initiative, improve their clinical skills and enhance the effect of learning, so as to improve the teaching quality. Conclusion The teaching mode of diversification as the core, the teaching mode focusing on clinical practice and the teaching mode of the comprehensive use of the Internet plus as the platform are introduced into the teaching of pediatric dermatology, which greatly improves the students’ practical ability to solve the problems and promotes the teaching of pediatric dermatology.