Abstract: Talent training is the fundamental task of higher medical education, and it is also an important embodiment of the social functions of medical colleges and universities. The construction of talent training mode in medical colleges and universities should meet the needs of social development and the people's demand for high quality medical service. It is an important task to promote the reform and development of medical education by establishing the training mode of medical talent guided by the idea of integration of organ system. This paper analyzes the development trend of comprehensive reform of clinical medical education, explains the practical significance in carrying out the reform of training medical talent through organ-centered curriculum mode, and explores how to promote the healthy development of higher medical education, combined with the practice of reform in medical colleges.