Abstract: Objective To explore the role of the application of PBL(problem-based learning) teaching method based on WeChat platform in hematology clinical practice. Methods Because the traditional medical teaching model had some problems, this article pointed out the importance of adopting problem-based learning. This study used Wechat as a platform for PBL in hematology clinical practice. Results WeChat platform with PBL teaching method in hematology clinical practice could arouse the enthusiasm of clinical medical students on learning, cultivate the ability of clinical thinking, enhance the communication between teachers and students, students and students, and boost the clinical teaching quality.Conclusion Based on WeChat platform of PBL teaching method can play an effective role in hematology clinical practice, which is worth further developing.